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KMID : 1149220020100020113
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Korean Journal of Oriental Medical Prescription
2002 Volume.10 No. 2 p.113 ~ p.126
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Studies on the antimetastasis & antiangiogenesis effects of Gamisoamsan
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Yoon Sung-Chan
Ahn Seong-Hun
Kim Jin-Kyeoung
Mun Yeun-Ja
Choo Young-Kug
Jung Kyu-Yong
Woo Won-Hong
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Abstract
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Soamsan is known as an anti-cancer remedy in the traditional Korean Medicine. To enhance the synergic effects of anti-cancer activity of Soamsan, this study reconstituted the original components of Soamsan with a slight modification and produced a novel herbal remedy, namely Gamisoamsan. Extracts of Gamisoamsan inhibited the growth of cultured CT-26 cells, mouse colon adenocarcinoma, in a dose-dependent manner (1 to 50 ㎍/㎖), and ID50 was estimated approximately 16.7㎍/㎖. Using tumor-bearing mouse model, in which was produced by subcutaneous injection of CT-26 cells (cells). the effects of Gamisoamsan on tumor growth and host survival were examined by evaluating tumor volume and increase in life span. When Gamisoamsan extracts in variable doses of 100, 200 and 500mg／kg body weight per day were orally administered to tumor-bearing mice, following results were obtained: Improvement in the hematological parameters following Gamisoamsan treatment such as hemoglobin contents, red blood cells and white blood cells of the tumor-bearing mice have been observed. Gamisoamsan treatment also showed a prolongation of life span and a reduction of tumor volume in the CT-26 tumor hosts. The results of the present study suggest that Gamisoamsan extracts has a potential anti-tumor activity and may be an useful remedy to prevent and／or treat cancer.
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KEYWORD
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